MindSpec published anoriginal research article in PLoS One detailing a predictive gene map for autism based on AutDB gene sets. After compiling a reference set of 84 autism genes, we profiled of their functions and expression patterns. We then screened the human genome to identify 442 potential novel autism candidate genes.
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MindSpec published a book chapter regarding the genetic heterogeneity of autism in a textbook by InTech Open Access titled “Autism Spectrum Disorders: The Role of Genetics in Diagnosis and Treatment.”
MindSpec published a description of the AutDB Animal Model module in BMC Medical Genomics. This module provides a comprehensive resource of ASD-related animal models which are linked to corresponding candidate genes in the original Human Gene module. Notably, animal models are annotated with a new standardized vocabulary of phenotypic terms called PhenoBase.
MindSpec Founder/President Sharmila Banerjee Basu collaborated with Alan Packer of the Simons Foundation to publish a commentary in Disease Models and Mechanisms about SFARI Gene, the version of AutDB licensed to the Simons Foundation.
Collaboration between MindSpec Founder/President Sharmila Banerjee-Basu and Simon Baron-Cohen, the Director of the Autism Research Centre at Cambridge University, resulted in a publication in Autism Research. The article described types of genes that they found to be associated with autistic traits, empathy, and Asperger syndrome: genes related to sex steroids, neural growth, and social-emotional behavior.