Eric Larsen, Ph.D.
Tel: 703-288-4420 8280 Greensboro Drive Suite 150
Fax: 703-288-4430 McLean, VA 22102
eric@mindspec.org
Publications:
Dr. Larsen received his B.S. at the University of Arizona in 1996 and his Ph.D. at the University of Wisconsin in 2004. His doctoral thesis dealt with characterizing the calcium-dependent interactions between proteins involved in the final steps of regulated exocytosis of neurotransmitters and neuromodulatory molecules from neurons and neuroendocrine cells. During his subsequent postdoctoral research projects, he used animal models of neurodegenerative disorders such as stroke and multiple sclerosis with the goal of developing potential therapeutic approaches in the treatment of these diseases.
His research at MindSpec is aimed at characterizing the significance of copy number variants (CNVs) in the development of autism.
Publications:
Research Articles
Wang Y, Piao JH, Larsen EC, Kondo Y, and Duncan ID (2011) Migration and remyelination by oligodendrocyte progenitor cells transplanted adjacent to focal areas of spinal cord inflammation. Journal of Neuroscience Research 89: 1737-1746.
Mayer JA, Larsen EC, Kondo Y, and Duncan ID (2011) Characterization of a PLP-overexpressing transgenic rat, a model for the connatal form of Pelizaeus-Merzbacher disease. Neurobiology of Disease 44: 231-238.
Converse AK, Larsen EC, Engle JW, Barnhart TE, Nickles RJ, and Duncan ID (2011) 11C-(R)-PK11195 PET imaging of microglial activation and response to minocycline in zymosan-treated rats. Journal of Nuclear Medicine 52: 257-262.
Larsen EC, Kondo Y, Fahrenholtz CD, and Duncan ID (2008) Generation of cultured oligodendrocyte progenitor cells from rat neonatal brains. Current Protocols in Stem Cell Biology 2D.1.1-2D.1.13.
Larsen EC, Hatcher JF, and Adibhatla RM (2007) Effect of tricyclodecan-9-yl potassium xanthate (D609) on phospholipid metabolism and cell death during oxygen-glucose deprivation in PC12 cells. Neuroscience 146: 946-961.
Lynch KL, Gerona RR, Larsen EC, Marcia RF, Mitchell JC, and Martin TF (2007) Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis. Molecular Biology of the Cell 18: 4957-4968.
Adibhatla RM, Hatcher JF, Larsen EC, Chen X, Sun D, and Tsao FH (2006) CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke. Journal of Biological Chemistry 281: 6718-6725.
Blackmer T, Larsen EC, Bartleson C, Kowalchyk JA, Yoon EJ, Preininger AM, Alford S, Hamm HE, and Martin TF (2005) G protein betagamma directly regulates SNARE protein fusion machinery for secretory granule exocytosis. Nature Neuroscience 8: 421-425.
Blackmer T, Larsen EC, Takahashi M, Martin TF, Alford S, and Hamm HE (2001) G protein betagamma subunit-mediated presynaptic inhibition: regulation of exocytotic fusion downstream of Ca2+ entry. Science 292: 293-297.
Gerona RR, Larsen EC, Kowalchyk JA, and Martin TF (2000) The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes. Journal of Biological Chemistry 275: 6328-6336.
Book Chapters
“Genetic Heterogeneity of Autism Spectrum Disorders.” Catherine Croft Swanwick, Eric C. Larsen, and Sharmila Banerjee-Basu. Autism Spectrum Disorders: The Role of Genetics in Diagnosis and Treatment. Williams, Tim (Ed.) InTech Open Access Publisher (2011).
“Transplantation of Stem Cells and Their Derivatives in the Treatment of Multiple Sclerosis.” Eric C. Larsen and Ian D. Duncan. Stem Cell Biology in Health and Disease. Dittmar, Thomas; Zanker, Kurt S. (Eds.) Springer (2010).