Ishita Das, Ph.D.
Tel: 703-288-4420 8280 Greensboro Drive Suite 150
Fax: 703-288-4430 McLean, VA 22102
ishita@mindspec.org
Publications:
Dr. Das received her B.Sc(H) degree from Delhi University, her M.S. in Biological Sciences from Indian Institute of Science, Bangalore and her Ph.D. from the Cellular and Molecular Physiology program at Johns Hopkins University, Baltimore. In her Masters she worked on the biophysical characteristics of periplasmic proteins and the role of their signal peptides in the folding process. During her Ph.D., she studied neuroanatomy and behavior of mouse models of Down syndrome(DS), testing a sonic hedgehog pathway based treatment regime that improves learning and memory as well as cerebellar dysmorphology in a DS model. Dr. Das joined Mindspec in 2012, her work focuses on updating and curating mouse model data in AutDB and configuration of the lexicon (PhenoBase) of animal model endophenotypes.
Publications:
Das, I., Park, J.-M., Shin, J. H., Jeon, S. K., Lorenzi, H., Linden, D. J., … Reeves, R. H. (2013). Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. Science Translational Medicine, 5(201), 201ra120. http://doi.org/10.1126/scitranslmed.3005983
Das, I., & Reeves, R. H. (2011). The use of mouse models to understand and improve cognitive deficits in Down syndrome. Disease Models & Mechanisms, 4(5), 596–606. http://doi.org/10.1242/dmm.007716
3: Moore, C. S., Hawkins, C., Franca, A., Lawler, A., Devenney, B., Das, I., & Reeves, R. H. (2010). Increased male reproductive success in Ts65Dn “Down syndrome” mice. Mammalian Genome, 21(11-12), 543–549. http://doi.org/10.1007/s00335-010-9300-8